Article
Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation.
Blood - 5 Apr 2012
Xi Liqiang, Arons Evgeny, Navarro Winnifred, Calvo Katherine R, Stetler-Stevenson Maryalice, Raffeld Mark, Kreitman Robert J
Abstract excerpt
Recently, the BRAF V600E mutation was reported in all cases of hairy cell leukemia (HCL) but not in other peripheral B-cell neoplasms. We wished to confirm these results and assess BRAF status in well-characterized cases of HCL associated with poor prognosis, including the immunophenotypically defined HCL variant (HCLv) and HCL expressing the IGHV4-34 immunoglobulin rearrangement. Fifty-three classic HCL (HCLc)...
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