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Article

The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3.

FEBS letters - 5 Jun 2002

Lee Meng-Huee, Verma Vandana, Maskos Klaus, Becherer J David, Knäuper Vera, Dodds Philippa, Amour Augustin, Murphy Gillian

Abstract excerpt

Tumor necrosis factor-alpha converting enzyme (TACE) is an ADAM (a disintegrin and metalloproteinases) that comprises an active catalytic domain and several C-terminal domains. We compare the binding affinity and association rate constants of the N-terminal domain form of wild-type tissue inhibitor of metalloproteinase (TIMP-3; N-TIMP-3) and its mutants against full-length recombinant TACE and the truncated form...

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Identifiers

PMID: 12044879
DOI: 10.1016/s0014-5793(02)02776-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3.PMID 12044879Read ↗

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