Article
Multiplex mapping of CD4 T cell epitopes using class II tetramers.
Clinical immunology (Orlando, Fla.) - 1 Jul 2006
Yang Junbao, James Eddie A, Huston Laurie, Danke Nancy A, Liu Andrew W, Kwok William W
Abstract excerpt
With the advent of class II tetramer technology, a tetramer-guided epitope mapping (TGEM) technique was developed for the identification of CD4+ T cell epitopes. This allowed the direct identification of epitopes recognized by the responding T cells, which were restricted to the single MHC allele of interest. However, as each individual carries multiple class II alleles, it would be advantageous to design an...
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