Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The rcbA gene product reduces spontaneous and induced chromosome breaks in Escherichia coli.

Journal of bacteriology - 1 May 2012

Felczak Magdalena M, Kaguni Jon M

Abstract excerpt

Elevated levels of DnaA cause excessive initiation, which leads to an increased level of double-strand breaks that are proposed to arise when newly formed replication forks collide from behind with stalled or collapsed forks. These double-strand breaks are toxic in mutants that are unable to repair them. Using a multicopy suppressor assay to identify genes that suppress this toxicity, we isolated a plasmid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Breakage
Share to Chromosomes, Bacterial
Share to DNA, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to DNA Helicases

Share to Escherichia coli Proteins

Share to Gene Expression Regulation, Bacterial

Share to Plasmids

Source

Open in PubMed Open full text

Identifiers

PMID: 22343303
DOI: 10.1128/JB.06390-11
PMCID: PMC3347072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The rcbA gene product reduces spontaneous and induced chromosome breaks in Escherichia coli.PMID 22343303Read ↗

Hyperinitiation of DNA replication in Escherichia coli leads to replication fork collapse and inviability.Semantic proximity Read ↗

RecBCD enzyme overproduction impairs DNA repair and homologous recombination in Escherichia coli.Semantic proximity Read ↗

The sequence requirements for a functional Escherichia coli replication origin are different for the chromosome and a minichromosome.Semantic proximity Read ↗

recA mutants of E. coli K12: a personal turning point.Semantic proximity Read ↗

Essential bacterial helicases that counteract the toxicity of recombination proteins.Semantic proximity Read ↗

Control of the endonuclease activity of type I restriction-modification systems is required to maintain chromosome integrity following homologous recombination.Semantic proximity Read ↗

Requirement of RecBC enzyme and an elevated level of activated RecA for induced stable DNA replication in Escherichia coli.Semantic proximity Read ↗

An improved recombineering approach by adding RecA to lambda Red recombination.Semantic proximity Read ↗

Critical role of RecA and RecF proteins in strand break rejoining and maintenance of fidelity of rejoining following gamma-radiation-induced damage to pMTa4 DNA in E. coli.Semantic proximity Read ↗

Modulation of DNA repair by mutations flanking the DNA channel through RNA polymerase.Semantic proximity Read ↗

The RdgC protein of Escherichia coli binds DNA and counters a toxic effect of RecFOR in strains lacking the replication restart protein PriA.Semantic proximity Read ↗

Influence of RecA protein on induced mutagenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.