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Article

Mutational effects on the cooperativity of Ca2+ binding in calmodulin.

Biochemistry - 10 Aug 1993

Waltersson Y, Linse S, Brodin P, Grundström T

Abstract excerpt

The importance of the aspartate ligand in the +Y Ca2+ coordinating position of two EF-hands of calmodulin has been investigated. Synthetic calmodulin genes were used to produce engineered proteins with the wild-type bovine sequence as well as with aspartate 58 in Ca(2+)-binding site II and/or aspartate 95 in site III changed to asparagine. The macroscopic Ca(2+)-binding constants of the intact calmodulins and of...

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Identifiers

PMID: 8347591
DOI: 10.1021/bi00082a005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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