Article
Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition.
Pediatric nephrology (Berlin, Germany) - 1 Mar 2005
Rosen Clifford J, Ackert-Bicknell Cheryl, Beamer Wesley G, Nelson Tracy, Adamo Martin, Cohen Pinchas, Bouxsein Mary L, Horowitz Mark C
Abstract excerpt
Insulin-like growth factor-I (IGF-I) is critical for optimal skeletal growth and maintenance. Knockout and transgenic models have provided significant insights into the role of IGF-I in bone modeling and remodeling. Congenic mice demonstrate allelic differences in particular quantitative trait loci (QTL). One such model is congenic 6T, which contains a QTL for reduced serum IGF-I donated from C3H/HeJ on a pure...
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