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Article

Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelial-mesenchymal transition reveals a migratory/invasive phenotype.

Journal of proteome research - 1 May 2006

Keshamouni Venkateshwar G, Michailidis George, Grasso Catherine S, Anthwal Shalini, Strahler John R, Walker Angela, Arenberg Douglas A, Reddy Raju C, Akulapalli Sudhakar, Thannickal Victor J, Standiford Theodore J, Andrews Philip C, Omenn Gilbert S

Abstract excerpt

Transforming growth factor-beta (TGF-beta) induces epithelial-mesenchymal transition (EMT) of epithelial cells in both normal embryonic development and certain pathological contexts. Here, we show that TGF-beta induced-EMT in human lung cancer cells (A549; adenocarcinoma cells) mediates tumor cell migration and invasion phenotypes. To gain insights into molecular events during EMT, we employed a global stable...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16674103
DOI: 10.1021/pr050455t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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