Article
Epithelial-mesenchymal transition-associated secretory phenotype predicts survival in lung cancer patients.
Carcinogenesis - 1 Jun 2014
Reka Ajaya Kumar, Chen Guoan, Jones Richard C, Amunugama Ravi, Kim Sinae, Karnovsky Alla, Standiford Theodore J, Beer David G, Omenn Gilbert S, Keshamouni Venkateshwar G
Abstract excerpt
In cancer cells, the process of epithelial-mesenchymal transition (EMT) confers migratory and invasive capacity, resistance to apoptosis, drug resistance, evasion of host immune surveillance and tumor stem cell traits. Cells undergoing EMT may represent tumor cells with metastatic potential. Characterizing the EMT secretome may identify biomarkers to monitor EMT in tumor progression and provide a prognostic...
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