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Proteomics of Smad4 regulated transforming growth factor-beta signalling in colon cancer cells

22 Sept 2010

Abstract excerpt

TGF-β signalling can play a paradoxical cell type specific role in cancer progression. Smad4 is a key mediator of the TGF-β pathway, and is mutated and/or deleted in many cancers. To investigate Smad4 regulated TGF-β signalling in colon cancer we conducted an iTRAQ mass spectrometry quantitative screen using wild type SW480 (Smad4 negative) colon carcinoma cells and stably restored Smad4 positive SW480 cells. In...

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PMID: 20862427
DOI: 10.1039/c0mb00016g

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