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Quantitative phosphoproteomics of transforming growth factor‐β signaling in colon cancer cells

14 Jun 2011

Abstract excerpt

The transforming growth factor-β (TGF-β) signaling pathway progresses through a series of protein phosphorylation regulated steps. Smad4 is a key mediator of the classical TGF-β signaling pathway; however, reports suggest that TGF-β can activate other cellular pathways independent of Smad4. By investigating the TGF-β-regulated phosphoproteome, we aimed to uncover new functions controlled by TGF-β. We applied...

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PMID: 21751366
DOI: 10.1002/pmic.201100036

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