Article
A genome-wide screen for nicotine dependence susceptibility loci.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2006
Swan Gary E, Hops Hyman, Wilhelmsen Kirk C, Lessov-Schlaggar Christina N, Cheng Li S-C, Hudmon Karen S, Amos Christopher I, Feiler Heidi S, Ring Huijun Z, Andrews Judy A, Tildesley Elizabeth, Benowitz Neal
Abstract excerpt
Genome-wide model free linkage analysis was conducted for nicotine dependence and tobacco use phenotypes in 607 members of 158 nuclear families consisting of at least two ever smokers (100 or more cigarettes smoked in lifetime). DNA from whole blood was genotyped for 739 autosomal microsatellite polymorphisms with an average inter-marker distance of 4.6 cM. A peak LOD score of 2.7 was observed on chromosome 6 for...
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