Article
Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus.
Biological psychiatry - 1 Jan 2007
Gelernter Joel, Panhuysen Carolien, Weiss Roger, Brady Kathleen, Poling James, Krauthammer Michael, Farrer Lindsay, Kranzler Henry R
Abstract excerpt
BACKGROUND: Nicotine dependence (ND) is costly to societies worldwide, moderately heritable, and genetically complex. Risk loci can be identified with genetic linkage analysis independent of prior physiological hypotheses. METHODS: We completed a genomewide linkage scan to map loci increasing risk for DSM-IV ND and for a quantitative assessment of ND as measured by the Fagerstrom Test for Nicotine Dependence...
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