Article
Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study.
Molecular psychiatry - 1 Mar 1999
Straub R E, Sullivan P F, Ma Y, Myakishev M V, Harris-Kerr C, Wormley B, Kadambi B, Sadek H, Silverman M A, Webb B T, Neale M C, Bulik C M, Joyce P R, Kendler K S
Abstract excerpt
Cigarette smoking is associated with considerable morbidity, mortality, and public health costs. Genetic factors influence both smoking initiation and nicotine dependence, but none of the genes involved have been identified. A genome scan using 451 markers was conducted to identify chromosomal regions linked to nicotine dependence in a collection of 130 families containing 343 genotyped individuals (308...
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