Article
Linkage of nicotine dependence and smoking behavior on 10q, 7q and 11p in twins with homogeneous genetic background.
The pharmacogenomics journal - 1 Jun 2008
Loukola A, Broms U, Maunu H, Widén E, Heikkilä K, Siivola M, Salo A, Pergadia M L, Nyman E, Sammalisto S, Perola M, Agrawal A, Heath A C, Martin N G, Madden P A F, Peltonen L, Kaprio J
Abstract excerpt
The significant worldwide health burden introduced by tobacco smoking highlights the importance of studying the genetic determinants of smoking behavior and the key factor sustaining compulsive smoking, that is, nicotine dependence (ND). We have here addressed the genetic background of smoking in a special study sample of twins, harmonized for early life events and specifically ascertained for smoking from the...
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