Article
Simultaneous detection of precore/basal core promoter mutations in hepatitis B virus using arrayed primer extension.
Molecular diagnosis & therapy - 1 Jan 2006
Ha Wai-Yan, Lau Chi-Chiu, Yue Patrick Y K, Hung Kaman K M, Chan Kelvin, Chui Siu-Hon, Chui Albert K K, Yam Wing-Cheong, Wong Ricky N S
Abstract excerpt
BACKGROUND: Hepatitis B is a major disease that causes serious public health problems worldwide. The loss of HBeAg expression due to point mutations or single nucleotide polymorphisms (SNPs) in the precore/basal core promoter region of the hepatitis B virus (HBV) is associated with hepatocellular cirrhosis and carcinoma. Simultaneous screening for these mutations is strongly advocated for monitoring disease...
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