Article
In vitro activity of sparfloxacin (CI-978, AT-4140, and PD 131501). A quinolone with high activity against gram-positive bacteria.
Diagnostic microbiology and infectious disease - 1 Jan 2000
Cohen M A, Huband M D, Mailloux G B, Yoder S L, Roland G E, Heifetz C L
Abstract excerpt
Sparfloxacin (CI-978, AT-4140 and PD 131501) is a new antimicrobial agent of the piperazinyl quinolone class. Relative to other quinolones, it is a potent antistaphylococcal and antistreptococcal drug in vitro: The microbroth 90% minimum inhibitory concentration (MIC90) (in microgram/ml) was 0.25 vs 26 methicillin-resistant and -sensitive coagulase-positive and -negative staphylococci and 20 Streptococcus...
Topics
- Anti-Infective Agents
- Drug Evaluation, Preclinical
- Drug Resistance, Microbial
- Enterococcus faecalis
- Fluoroquinolones
- Gram-Negative Bacteria
- Gram-Positive Bacteria
- Microbial Sensitivity Tests
- Mutation
- Quinolones