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Article

In vitro activity of sparfloxacin (CI-978, AT-4140, and PD 131501). A quinolone with high activity against gram-positive bacteria.

Diagnostic microbiology and infectious disease - 1 Jan 2000

Cohen M A, Huband M D, Mailloux G B, Yoder S L, Roland G E, Heifetz C L

Abstract excerpt

Sparfloxacin (CI-978, AT-4140 and PD 131501) is a new antimicrobial agent of the piperazinyl quinolone class. Relative to other quinolones, it is a potent antistaphylococcal and antistreptococcal drug in vitro: The microbroth 90% minimum inhibitory concentration (MIC90) (in microgram/ml) was 0.25 vs 26 methicillin-resistant and -sensitive coagulase-positive and -negative staphylococci and 20 Streptococcus...

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PMID: 1665775
DOI: 10.1016/0732-8893(91)90067-p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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