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Article

Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis.

Journal of molecular medicine (Berlin, Germany) - 1 Oct 2005

Vogler Susanne, Goedde René, Miterski Bianca, Gold Ralf, Kroner Antje, Koczan Dirk, Zettl Uwe-Klaus, Rieckmann Peter, Epplen Joerg T, Ibrahim Saleh M

Abstract excerpt

Uncoupling protein 2 (UCP2) is a member of the mitochondrial proton transport family that uncouples proton entry to the mitochondria from ATP synthesis. UCP2 expression levels have been linked to predisposition to diabetes and obesity. In addition, UCP2 prevents neuronal death and injury. Here we show that the common -866G/A promoter polymorphism is associated with susceptibility to multiple sclerosis (MS) in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16021520
DOI: 10.1007/s00109-005-0661-5

Genes

UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis.PMID 16021520Read ↗

Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases.Semantic proximity Read ↗

A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans.Semantic proximity Read ↗

The common -866G/A polymorphism of the UCP2 gene in healthy Iranians compared with world populations.Semantic proximity Read ↗

The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy.Semantic proximity Read ↗

Genetic Variance in<i>Uncoupling Protein 2</i>in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional −866G>A Promoter Variant (rs659366)Semantic proximity Read ↗

A common polymorphism in the promoter of UCP2 is associated with obesity and hyperinsulenemia in northern Indians.Semantic proximity Read ↗

UCP2 and mitochondrial haplogroups as a multiple sclerosis risk factor.Semantic proximity Read ↗

Mitochondrial uncoupling protein 2 (UCP2) gene polymorphism - 866 G/A in the promoter region is associated with type 2 diabetes mellitus among Kashmiri population of Northern India.Semantic proximity Read ↗

A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects.Semantic proximity Read ↗

Associations between polymorphisms in the mitochondrial uncoupling proteins (UCPs) with T2DM.Semantic proximity Read ↗

A polymorphism in the promoter of UCP2 gene modulates lipid levels in patients with type 2 diabetes.Semantic proximity Read ↗

UCP2, a mitochondrial protein regulated at multiple levels.Semantic proximity Read ↗

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