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Article

Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype.

Oncogene - 14 Jul 2005

Eom Young-Woo, Kim Mi Ae, Park Seok Soon, Goo Mi Jin, Kwon Hyuk Jae, Sohn Seonghyang, Kim Wook-Hwan, Yoon Gyesoon, Choi Kyeong Sook

Abstract excerpt

Chronic exposure of many human hepatoma cell lines to a low dose (LD) of doxorubicin induced a senescence-like phenotype (SLP) accompanied by enlargement of cells and increased senescence-associated beta-galactosidase activity. LD doxorubicin-induced SLP was preceded by multinucleation and downre...

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Identifiers

PMID: 15870702
DOI: 10.1038/sj.onc.1208627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15870702-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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