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Article

Distinct mechanisms of site‐specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH‐cytochrome P450 reductase

1 Aug 2003

Abstract excerpt

The anticancer mechanism of doxorubicin (DOX), an anthracycline antibiotic, is believed to involve DNA damage through topoisomerase II inhibition and free radical generation. The free radical generation may also participate in genotoxicity, as well as cardiotoxicity, in normal human cells. The present study showed that DOX generates 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG), an indicator of oxidative DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12901793
DOI: 10.1111/j.1349-7006.2003.tb01503.x

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