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Article

Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2.

Free radical biology & medicine - 1 Nov 2007

White Shai J, Kasman Laura M, Kelly Margaret M, Lu Ping, Spruill Laura, McDermott Paul J, Voelkel-Johnson Christina

Abstract excerpt

We have previously shown that doxorubicin sensitizes prostate cancer cells to tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL). Sensitization correlated with decreased expression of the antiapoptotic cellular FLICE-like inhibitor protein (cFLIP(S)). The decrease in cFLIP(S) could not be explained by transcriptional regulation or increased degradation, leading us to focus on translational...

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Identifiers

PMID: 17893044
DOI: 10.1016/j.freeradbiomed.2007.06.015
PMCID: PMC2084083

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XIAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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