Article
Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs.
PloS one - 1 Jan 2015
Zhu Christopher, Nigam Kabir B, Date Rishabh C, Bush Kevin T, Springer Stevan A, Saier Milton H, Wu Wei, Nigam Sanjay K
Abstract excerpt
The SLC22 family includes organic anion transporters (OATs), organic cation transporters (OCTs) and organic carnitine and zwitterion transporters (OCTNs). These are often referred to as drug transporters even though they interact with many endogenous metabolites and signaling molecules (Nigam, S.K., Nature Reviews Drug Discovery, 14:29-44, 2015). Phylogenetic analysis of SLC22 supports the view that these...
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