Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA damage responses in Drosophila nbs mutants with reduced or altered NBS function.

DNA repair - 4 Jul 2009

Mukherjee Sushmita, LaFave Matthew C, Sekelsky Jeff

Abstract excerpt

The MRN complex, composed of MRE11, RAD50 and NBS, plays important roles in responding to DNA double-strand breaks (DSBs). In metazoans, functional studies of genes encoding these proteins have been challenging because complete loss-of-function mutations are lethal at the organismal level and because NBS has multiple functions in DNA damage responses. To study functions of Drosophila NBS in DNA damage responses,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to DNA Breaks, Double-Stranded
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Drosophila

Share to Drosophila Proteins

Share to Gamma Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 19395318
DOI: 10.1016/j.dnarep.2009.03.004
PMCID: PMC2702778

Genes

MRE11
NBN
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA damage responses in Drosophila nbs mutants with reduced or altered NBS function.PMID 19395318Read ↗

NBS1 and its functional role in the DNA damage response.Semantic proximity Read ↗

The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage.Semantic proximity Read ↗

The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability.Semantic proximity Read ↗

Targeted disruption of NBS1 reveals its roles in mouse development and DNA repairSemantic proximity Read ↗

Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells.Semantic proximity Read ↗

A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin.Semantic proximity Read ↗

The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity.Semantic proximity Read ↗

Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance.Semantic proximity Read ↗

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.Semantic proximity Read ↗

DNA repair defects and other (mus)takes in Drosophila melanogaster.Semantic proximity Read ↗

NBS1 interacts with HP1 to ensure genome integrity.Semantic proximity Read ↗

Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.