Different transport activity of human triallelic MDR1 893Ala/Ser/Thr variant and its association with herb extracts.

doi:10.1002/ptr.3405

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Article

Different transport activity of human triallelic MDR1 893Ala/Ser/Thr variant and its association with herb extracts.

Phytotherapy research : PTR - 1 Aug 2011

Kim Jeong-Hyun, Kim Soon Re, Song Im-Sook, Shin Ho-Jung, Kim Han-Seop, Lee Jung-Ha, Ko Seong-Gyu, Shin Yong-Cheol

Abstract excerpt

Individual pharmacokinetic differences for herb-drug interaction have been associated with genetic variations of the multidrug resistance (MDR) gene. A high level expression of MDR protein increases cellular efflux and might decrease drug sensitivity. This study investigated the drug efflux activity difference of human MDR1 triallelic variant 2677G/T/A (rs2032582), as a nonsynonymous 893Ala/Ser/Thr, using Xenopus...

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PMID: 21287651
DOI: 10.1002/ptr.3405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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