Article
Evolution of inhibitor-resistant natural mutant forms of HIV-1 protease probed by pre-steady state kinetic analysis.
Biochimie - 1 Nov 2017
Zakharova Maria Yu, Kuznetsova Alexandra A, Kaliberda Elena N, Dronina Maria A, Kolesnikov Alexander V, Kozyr Arina V, Smirnov Ivan V, Rumsh Lev D, Fedorova Olga S, Knorre Dmitry G, Gabibov Alexander G, Kuznetsov Nikita A
Abstract excerpt
Pre-steady state kinetic analysis of mechanistic features of substrate binding and processing is crucial for insight into the evolution of inhibitor-resistant forms of HIV-1 protease. These data may provide a correct vector for rational drug design assuming possible intrinsic dynamic effects. These data should also give some clues to the molecular mechanism of protease action and resistance to inhibitors. Here we...
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