Article
Ex vivo selection and expansion of cells based on expression of a mutated inosine monophosphate dehydrogenase 2 after HIV vector transduction: effects on lymphocytes, monocytes, and CD34+ stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2006
Yam Priscilla, Jensen Michael, Akkina Ramesh, Anderson Joseph, Villacres Maria C, Wu Jerry, Zaia John A, Yee Jiing-Kuan
Abstract excerpt
Hematopoietic progenitor cells (HPCs) represent an ideal target for gene therapy treatment of human immunodeficiency virus (HIV) infection. However, gene delivery into quiescent HPCs by retroviral or lentiviral vectors remains relatively poor. We evaluated a selection scheme based on the expressi...
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