Article
Inosine Triphosphate Pyrophosphohydrolase Expression: Decreased in Leukocytes of HIV-Infected Patients Using Combination Antiretroviral Therapy.
Journal of acquired immune deficiency syndromes (1999) - 1 Dec 2016
Peltenburg N Chantal, Leers Mathie P G, Bakker Jaap A, Lowe Selwyn H, Vroemen Wim H M, Paulussen Aimée D C, van den Bosch Bianca J C, Bierau Jörgen, Verbon Annelies
Abstract excerpt
OBJECTIVE: In HIV-infected patients, the enzyme Inosine triphosphate pyrophosphohydrolase (ITPase), involved in purine nucleotide homeostasis, was found to be decreased in erythrocytes. Since purine analogues are pivotal in the HIV treatment, a better understanding of ITPase expression in CD4 lymphocytes may lead to better understanding of nucleotide metabolism and (adverse) effects. DESIGN: Cross-sectional,...
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