Article
Identification and characterization of p49/STRAP as a novel GLUT4-binding protein.
Biochemical and biophysical research communications - 16 Jun 2006
Lisinski Ivonne, Matsumoto Hideko, Yver Dena R, Schürmann Annette, Cushman Samuel W, Al-Hasani Hadi
Abstract excerpt
To identify novel regulatory components involved in the recycling of the insulin-responsive glucose transporter GLUT4, we have used the yeast two-hybrid system to isolate GLUT4-binding proteins from a rat adipose cell cDNA library. We found a 49-kDa protein (p49/STRAP) that specifically interacts with an acidic amino acid motif (Q7IGSEDG) in the N-terminus of GLUT4. Confocal immunofluorescence microscopy of...
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