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Article

Polymorphisms of methylenetetrahydrofolate reductase are associated with a high risk of nasopharyngeal carcinoma in a smoking population from Southern China.

Molecular carcinogenesis - 1 Nov 2010

Cao Yun, Miao Xiao-Ping, Huang Ma-Yan, Deng Ling, Liang Xiao-Man, Lin Dong-Xin, Zeng Yi-Xin, Shao Jian-Yong

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) plays a central role in converting folate to a compound which serves as a methyl donor for DNA methylation, an epigenetic modification known to be dysregulated in carcinogenesis. This case-control study assessed the contribution of MTHFR polymorphisms to the risk of nasopharyngeal carcinoma (NPC). MTHFR genotypes C677T and A1298C in 529 NPC patients and 577...

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Source

Identifiers

PMID: 20721969
DOI: 10.1002/mc.20669

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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