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Article

Drosophila activated Cdc42 kinase has an anti-apoptotic function.

PLoS genetics - 1 Jan 2012

Schoenherr Jessica A, Drennan J Michelle, Martinez Juan S, Chikka Madhusudana Rao, Hall Mark C, Chang Henry C, Clemens James C

Abstract excerpt

Activated Cdc42 kinases (Acks) are evolutionarily conserved non-receptor tyrosine kinases. Activating somatic mutations and increased ACK1 protein levels have been found in many types of human cancers and correlate with a poor prognosis. ACK1 is activated by epidermal growth factor (EGF) receptor signaling and functions to regulate EGF receptor turnover. ACK1 has additionally been found to propagate downstream...

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Identifiers

PMID: 22615583
DOI: 10.1371/journal.pgen.1002725
PMCID: PMC3355085

Genes

EGF
GRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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