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Article

Denaturing high-performance liquid chromatography: a valid approach for identifying NPM1 mutations in acute myeloid leukemia.

The Journal of molecular diagnostics : JMD - 1 May 2006

Roti Giovanni, Rosati Roberto, Bonasso Rossella, Gorello Paolo, Diverio Daniela, Martelli Massimo Fabrizio, Falini Brunangelo, Mecucci Cristina

Abstract excerpt

NPM1 gene mutations are the most frequent genetic lesion in the 60% of adult acute myeloid leukemias (AMLs) with normal karyotype and no evidence of typical fusion genes (BCR/ABL1, PML/RARA, AML1/ETO, CBFB/MYH11, DEK/CAN). Using direct sequencing we previously identified six different heterozygous mutants within exon 12 encoding the nucleophosmin C-terminus. Because of these mutations the shuttling protein...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, High Pressure Liquid

Share to Cytoplasm

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 16645213
DOI: 10.2353/jmoldx.2006.050098
PMCID: PMC1867590

Genes

NPM1
ABL1
BCR
CBFB
DEK
MYH11
PML
RARA

Provenance

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