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Article

Detection of nucleophosmin 1 mutations by quantitative real-time polymerase chain reaction versus capillary electrophoresis: a comparative study.

Archives of pathology & laboratory medicine - 1 Aug 2011

Barakat Fareed H, Luthra Rajyalakshmi, Yin C Cameron, Barkoh Bedia A, Hai Seema, Jamil Waqar, Bhakta Yaminiben I, Chen Su, Medeiros L Jeffrey, Zuo Zhuang

Abstract excerpt

CONTEXT: Nucleophosmin 1 (NPM1) is the most commonly mutated gene in acute myeloid leukemia. Detection of NPM1 mutations is useful for stratifying patients for therapy, predicting prognosis, and assessing for minimal residual disease. Several methods have been developed to rapidly detect NPM1 mutations in genomic DNA and/or messenger RNA specimens. OBJECTIVE: To directly compare a quantitative real-time...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21809990
DOI: 10.5858/2010-0490-OAR1

Genes

NPM1

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