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Article

Detection of the nucleophosmin gene mutations in acute myelogenous leukemia through RT-PCR and polyacrylamide gel electrophoresis.

European journal of haematology - 1 Jan 2009

Calvo Karina Lucrecia, Ojeda Mara Jorgelina, Ammatuna Emanuele, Lavorgna Serena, Ottone Tiziana, Targovnik Hector Manuel, Lo-Coco Francesco, Noguera Nélida Inés

Abstract excerpt

OBJECTIVES: Mutations in the C-terminal region of the nucleophosmin (NPM1) gene occur in approximately 60% of acute myeloid leukemia (AML) cases with normal karyotype and represent the most common genetic lesion presently known in this disease. Because of their frequency and favorable impact on prognostic outcome, screening for this aberration is currently recommended in routine diagnostic characterization of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 18801061
DOI: 10.1111/j.1600-0609.2008.01155.x

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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