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Article

Differential functions of multiple Wnts and receptors in cell polarity regulation in Caenorhabditis elegans.

Genetics - 4 Mar 2026

Sawa Hitoshi, Asakawa Masayo, Negishi Takefumi

Abstract excerpt

Metazoan species possess multiple Wnt ligands and receptor genes that regulate diverse developmental processes. Because these genes often act redundantly, analysis of single-gene mutants does not necessarily reveal the full roles of Wnt signaling. In Caenorhabditis elegans, 3 Wnt genes (cwn-1, egl-20, and cwn-2) and 3 receptor genes (lin-17/Fzd, mom-5/Fzd, and cam-1/Ror) redundantly regulate the polarity of...

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PMID: 41507057
DOI: 10.1093/genetics/iyag004

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