Article
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder.
American journal of human genetics - 1 May 2006
Hu Xian-Zhang, Lipsky Robert H, Zhu Guanshan, Akhtar Longina A, Taubman Julie, Greenberg Benjamin D, Xu Ke, Arnold Paul D, Richter Margaret A, Kennedy James L, Murphy Dennis L, Goldman David
Abstract excerpt
A functional serotonin transporter promoter polymorphism, HTTLPR, alters the risk of disease as well as brain morphometry and function. Here, we show that HTTLPR is functionally triallelic. The L(G) allele, which is the L allele with a common G substitution, creates a functional AP2 transcription-factor binding site. Expression assays in 62 lymphoblastoid cell lines representing the six genotypes and in...
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