Article
Association study of the serotonin transporter gene polymorphism in obsessive-compulsive disorder.
The international journal of neuropsychopharmacology - 1 Sept 2001
Camarena B, Rinetti G, Cruz C, Hernández S, de la Fuente J R, Nicolini H
Abstract excerpt
The hypothesis implicating the serotonergic system in the pathophysiology of obsessive-compulsive disorder (OCD) is supported by the therapeutic efficacy of selective serotonin reuptake inhibitors (SSRIs). Since SSRIs act on the serotonin transporter (5-HTT), it has been suggested that the 5-HTT gene (SCL6A4) could be a good candidate for OCD. The SCL6A4 gene has a 44-bp insertion/deletion polymorphism in its...
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