Article
Identification and functional characterization of three novel alleles for the serotonin transporter-linked polymorphic region.
Molecular psychiatry - 1 Feb 2012
Ehli E A, Hu Y, Lengyel-Nelson T, Hudziak J J, Davies G E
Abstract excerpt
A promoter polymorphism in the serotonin transporter gene (5-HTTLPR) has been reported to confer relative risk for phenotypes (depression/anxiety) and endophenotypes (amygdala reactivity). In this report, we identify and characterize three rare 5-HTTLPR alleles not previously described in the human literature. The three novel alleles were identified while genotyping 5-HTTLPR in a family-based attention deficit...
Topics
- Adolescent
- Alleles
- Attention Deficit Disorder with Hyperactivity
- Binding Sites
- Cell Line, Transformed
- Checklist
- Child
- Child, Preschool
- Family Health
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Humans