Article
Mutations truncating the EP300 acetylase in human cancers.
Nature genetics - 1 Mar 2000
Gayther S A, Batley S J, Linger L, Bannister A, Thorpe K, Chin S F, Daigo Y, Russell P, Wilson A, Sowter H M, Delhanty J D, Ponder B A, Kouzarides T, Caldas C
Abstract excerpt
The EP300 protein is a histone acetyltransferase that regulates transcription via chromatin remodelling and is important in the processes of cell proliferation and differentiation. EP300 acetylation of TP53 in response to DNA damage regulates its DNA-binding and transcription functions. A role for EP300 in cancer has been implied by the fact that it is targeted by viral oncoproteins, it is fused to MLL in...
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