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Article

Tunnel plasticity and quaternary structural integrity of a pentameric protein ring.

Protein science : a publication of the Protein Society - 1 May 2006

Woycechowsky Kenneth J, Seebeck Florian P, Hilvert Donald

Abstract excerpt

Cyclic protein oligomers are common in cells. However, the importance of the residues that line the central tunnel of protein rings for overall architectural integrity is not well understood. To investigate the role of tunnel positions in protein assembly and stability, we prepared variants of the homo-pentameric lumazine synthase (LS) from Saccharomyces cerevisiae in which the three residues that line the middle...

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Identifiers

PMID: 16641488
DOI: 10.1110/ps.052044606
PMCID: PMC2242520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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