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Article

Modeling of mutant superoxide dismutase 1 octamers with cross-linked disulfide bonds.

Journal of molecular modeling - 12 Mar 2022

Zhang Aidan, Teigen Knut, Kouznetsova Valentina L, Tsigelny Igor F

Abstract excerpt

Mutant superoxide dismutase 1 (SOD1) may form cyclic structures due to its greater instability from aberrant demetallization and oxidation of cysteine bonds. This cyclic structure may allow SOD1 to form ion channels on membranes such as the mitochondrial membrane, causing imbalances in the concentration of intracellular ions as a potential mechanism for the progressive neuron death involved in amyotrophic lateral...

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Identifiers

PMID: 35279789
DOI: 10.1007/s00894-022-05072-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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