Article
Nicotine metabolism and CYP2A6 allele frequencies in Koreans.
Pharmacogenetics - 1 Jun 2001
Kwon J T, Nakajima M, Chai S, Yom Y K, Kim H K, Yamazaki H, Sohn D R, Yamamoto T, Kuroiwa Y, Yokoi T
Abstract excerpt
CYP2A6 is a major catalyst of nicotine metabolism to cotinine. Previously, we demonstrated that the interindividual difference in nicotine metabolism is related to a genetic polymorphism of the CYP2A6 gene in Japanese. To clarify the ethnic differences in nicotine metabolism and frequencies of CYP2A6 alleles, we studied nicotine metabolism and the CYP2A6 genotype in 209 Koreans. The cotinine/nicotine ratio of the...
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