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Article

A yeast assay probes the interaction between botulinum neurotoxin serotype B and its SNARE substrate.

Proceedings of the National Academy of Sciences of the United States of America - 2 May 2006

Fang Hong, Luo Wentian, Henkel Jim, Barbieri Joseph, Green Neil

Abstract excerpt

The seven functionally distinct serotypes (A-G) of botulinum neurotoxin (BoNT) are dichains consisting of light chain (LC) with zinc-dependent endoprotease activity connected by one disulfide bond to heavy chain with neuronal-cell translocation and receptor-binding domains. LC-mediated proteolysis of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins and consequent inhibition...

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Identifiers

PMID: 16636286
DOI: 10.1073/pnas.0510816103
PMCID: PMC1447522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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