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Article

An elementary mathematical modeling of drug resistance in cancer.

Mathematical biosciences and engineering : MBE - 2 Dec 2020

Bao Kangbo

Abstract excerpt

Targeted therapy is one of the promising strategies for the treatment of cancer. However, resistance to anticancer drug strongly limits the long-term effectiveness of treatment, which is a major obstacle for successfully treating cancer. In this paper, we analyze a linear system of ordinary differential equations for cancer multi-drug resistance induced mainly by random genetic point mutation. We investigate that...

Topics

Antineoplastic Agents
Drug Resistance, Neoplasm
Humans
Models, Theoretical
Mutation
Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33525095
DOI: 10.3934/mbe.2021018

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