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Article

Insights into a divergent phenazine biosynthetic pathway governed by a plasmid-born esmeraldin gene cluster.

Chemistry & biology - 21 Sept 2012

Rui Zhe, Ye Min, Wang Shuoguo, Fujikawa Kaori, Akerele Bankole, Aung May, Floss Heinz G, Zhang Wenjun, Yu Tin-Wein

Abstract excerpt

Phenazine-type metabolites arise from either phenazine-1-carboxylic acid (PCA) or phenazine-1,6-dicarboxylic acid (PDC). Although the biosynthesis of PCA has been studied extensively, PDC assembly remains unclear. Esmeraldins and saphenamycin, the PDC originated products, are antimicrobial and antitumor metabolites isolated from Streptomyces antibioticus Tü 2706. Herein, the esmeraldin biosynthetic gene cluster...

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PMID: 22999880
DOI: 10.1016/j.chembiol.2012.07.025

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PDC

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