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Article

Deoxyribonucleic Acid Damage and Spontaneous Mutagenesis in the Thyroid Gland of Rats and Mice

21 Apr 2006

Abstract excerpt

Thyroid tumors are a frequent finding not only in iodine-deficient regions. They are predominantly characterized by somatic genetic changes (e.g. point mutations or rearrangements). Because slow thyroid proliferation is a apparent contradiction to a high frequency of tumor initiation, we characterized mutational events in thyroid. First we studied the frequency of certain base exchanges in somatic TSH receptor...

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PMID: 16627585
DOI: 10.1210/en.2005-1669

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Source receipt: pubmed, retrieved 7 Sept 2026.

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