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Article

Differential mutation frequency in mitochondrial DNA from thyroid tumours.

Carcinogenesis - 1 Oct 2002

Lohrer H D, Hieber L, Zitzelsberger H

Abstract excerpt

Lack of a chromatin structure and histone protection makes mitochondrial DNA susceptible to oxidative damage. Suboptimal DNA repair leads to a higher frequency of mitochondrial mutations, which are associated with aging, carcinogenesis and environmental insult. The instability of the hypervariable region II of the mitochondrial genome was investigated in radiation-associated thyroid tumours, which were diagnosed...

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PMID: 12376464
DOI: 10.1093/carcin/23.10.1577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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