Analysis of Short-Term and Stable DNA Damage in Patients with Differentiated Thyroid Cancer Treated with 131I in Hypothyroidism or with Recombinant Human Thyroid-Stimulating Hormone for Remnant Ablation

Abstract excerpt

It is well known that ionizing radiations can induce genetic damage and that oxidative stress is a major factor inducing it. Our aim was to investigate whether thyroid remnant ablation with low activities of 131I (1850 MBq), is associated with DNA damage by evaluating Comet assay, micronuclei and chromosome aberrations with multicolor fluorescent in situ hybridization (M-FISH). Methods: we studied 62 patients...

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