Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estrogen regulates development of the somatic cell phenotype in the eutherian ovary.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2002

Britt Kara L, Kerr Jeff, O'Donnell Liza, Jones Margaret E E, Drummond Ann E, Davis Susan R, Simpson Evan R, Findlay Jock K

Abstract excerpt

Steroids play a critical role in gonadal differentiation in birds, reptiles, and amphibia whereas gonadal differentiation in mammals is thought to be determined by genetic mechanisms. The gonads of female mice incapable of synthesizing estrogens due to disruption of the aromatase gene (ArKO) provide a unique model to test the role of estrogen in regulating the gonadal phenotype. We have shown that in the absence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aromatase
Share to Gonadotropins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Granulosa Cells

Share to High Mobility Group Proteins

Share to Isoflavones

Share to Leydig Cells

Share to Sertoli Cells

Share to SOX9 Transcription Factor

Source

Identifiers

PMID: 12205030
DOI: 10.1096/fj.01-0992com

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estrogen regulates development of the somatic cell phenotype in the eutherian ovary.PMID 12205030Read ↗

Regulation of the phenotype of ovarian somatic cells by estrogen.Semantic proximity Read ↗

Estrogen actions in the ovary revisited.Semantic proximity Read ↗

Contrasting phenotypes in reproductive tissues of female estrogen receptor null mice.Semantic proximity Read ↗

Effects of phytoestrogens on the ovarian and pituitary phenotypes of estrogen-deficient female aromatase knockout mice.Semantic proximity Read ↗

The phenotype of the aromatase knockout mouse reveals dietary phytoestrogens impact significantly on testis function.Semantic proximity Read ↗

Estrogen-Dependent Gene Expression in the Mouse OvarySemantic proximity Read ↗

The road to ovulation: the role of oestrogensSemantic proximity Read ↗

Expression of Sox9 in granulosa cells lacking the estrogen receptors, ERalpha and ERbeta.Semantic proximity Read ↗

Exogenous Oestrogen Impacts Cell Fate Decision in the Developing Gonads: A Potential Cause of Declining Human Reproductive HealthSemantic proximity Read ↗

Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult.Semantic proximity Read ↗

Gene knockout analysis reveals essentiality of estrogen receptor β1 (Esr2a) for female reproduction in medakaSemantic proximity Read ↗

Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.