Article
Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis.
Human immunology - 1 Mar 2003
Nejentsev Sergey, Laaksonen Mikko, Tienari Pentti J, Fernandez Oscar, Cordell Heather, Ruutiainen Juhani, Wikström Juhani, Pastinen Tomi, Kuokkanen Satu, Hillert Jan, Ilonen Jorma
Abstract excerpt
Intercellular adhesion molecule-1 (ICAM-1) is involved in the pathogenesis of multiple sclerosis (MS), whereas sequence variations in the ICAM-1 gene could potentially be responsible for the genetic susceptibility to MS. We studied an association of MS with the 13,848A>G (K469E) polymorphism of the ICAM-1 gene in Finnish and Spanish cases and controls and affected families. An increased risk for the AA...
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