Article
The single nucleotide polymorphism g.1548A >G (K469E) of the ICAM-1 gene is associated with worse prognosis in non-small cell lung cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Oct 2012
Thanopoulou Eirini, Kotzamanis George, Pateras Ioannis S, Ziras Nicholaos, Papalambros Alexandros, Mariolis-Sapsakos Theodoros, Sigala Fragiska, Johnson Elizabeth, Kotsinas Athanassios, Scorilas Andreas, Gorgoulis Vassilis G
Abstract excerpt
Intercellular adhesion molecule-1 (ICAM-1), a cell adhesion molecule with a key role in inflammation and immunosurveillance, has been implicated in carcinogenesis by facilitating instability of the tumor environment. The K469E single nucleotide polymorphism (SNP) (G>A) affects the ICAM-1 mRNA splicing pattern; the alternatively spliced isoform (ICAM-1-S) lacks transmembrane and intracellular domain, which affects...
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