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Article

RNA interference as a key to knockdown overexpressed cyclooxygenase-2 gene in tumour cells.

British journal of cancer - 8 May 2006

Strillacci A, Griffoni C, Spisni E, Manara M C, Tomasi V

Abstract excerpt

Silencing those genes that are overexpressed in cancer and contribute to the survival and progression of tumour cells is the aim of several researches. Cyclooxygenase-2 (COX-2) is one of the most intensively studied genes since it is overexpressed in most tumours, mainly in colon cancer. The use of specific COX-2 inhibitors to treat colon cancer has generated great enthusiasm. Yet, the side effects of some...

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Identifiers

PMID: 16622456
DOI: 10.1038/sj.bjc.6603094
PMCID: PMC2361412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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